孙小明
杭州师范大学基础医学院教授、硕士/博士生导师
个人简介：
博士毕业于日本熊本大学医学院，随后赴美国哈佛大学医学院Ragon研究所从事人体病毒免疫学研究。主要研究方向为在急性、慢性病毒感染过程中, 人体外周血中树突状细胞 (DC)和细胞杀伤性T细胞的反应作用机制。已发表SCI研究论文20余篇，其中以第一作者身份在PNAS, Nature Communications, Cell Reports, J. Immunol 等重要期刊发表过论文，被引用2800余次，H-index 17。
教育经历：
2004-2008 温州医科大学 理学学士
2008-2010 日本国立长崎大学 医齿药硕士
2010-2014 日本国立熊本大学 医学博士
工作经历：
2014-2015 日本熊本大学医学院 博士后
2015-2020 哈佛医学院/麻省总医院 博士后
2020-2021 哈佛医学院/麻省总医院 资深研究员
2021年12月-至今 杭州师范大学基础医学院 教授
2022年4月-至今 浙江大学传染病重症诊治全国重点实验室 兼任专家
学术兼职：
浙江省医学会病毒学分会委员
浙江省医学会微生物与免疫学分会委员
浙江省免疫学会感染免疫分会委员
研究方向:
1)慢性病毒感染过程中的免疫反应机制研究和免疫治疗应用开发。
2)利用系统免疫学方法解析人类自身免疫性水疱病发病机。
电子邮箱：xiaoming@hznu.edu.cn
学术成果：
1.Dan Zhang , Mengna Zhang, Liqin Zhang, Weijuan Wang, Stephane Hua, Chan Zhou , Xiaoming Sun. Long non-coding RNAs and immune cells: Unveiling the role in viral infections.Biomedicine & Pharmacotherapy 2023/12/06 DOI:https://doi.org/10.1016/j.biopha.2023.115978.
2.Yanhui Yang*,Yangmin Gao*, Mengna Zhang , Hua Qian , Ke Zhao , Weijuan Wang , Yanxiu Ma , Dan Zhang , Xiaoguang Li , Fengming Hu , Xiaoming Sun. Genetic diagnosis of a rare COL7A1 variant causing dystrophic epidermolysis bullosa pruriginosa through whole‑exome sequencing. Experimental and Therapeutic Medicine 2023/9/11 DOI: 10.3892/etm.
3. Behzad Etemad*, Xiaoming Sun*, Yijia Li* +24，Michael M. Lederman, Xu G. Yu, and Jonathan Z. Li. HIV post-treatment controllers have distinct immunological and virological features .PNAS. 2023,March 6.Vol. 120 No. 11 e2218960120
4. Weijun Liu , Xiaoming Sun , Yangmin Gao, Huicheng Li , Luhuai Shi , Lifang Cheng , Zhijun Zhou , Xiaoguang Li , Hua Qian. A Chinese case of concurrent anti-laminin γ1 pemphigoid and anti-laminin 332-type mucous membrane pemphigoid.The Journal of dermatology. 2022. PMID: 35811504 DOI:10.1111/1346-8138.16513
5.Xiaoming Sun.; Gao, C.; Zhao, K.; Yang, Y.; Rassadkina, Y.; Fajnzylber, J.; Regan, J.; Li, J. Z.; Lichterfeld, M.; Yu, X. G. Immune-Profiling of SARS-CoV-2 Viremic Patients Reveals Dysregulated Innate Immune Responses. Front. Immunol. 2022,11.13(984553)
6. Kevin B Einkauf, Matthew R Osborn, Ce Gao, Weiwei Sun, Xiaoming Sun, Xiaodong Lian, Elizabeth M Parsons, Gregory T Gladkov, Kyra W Seiger, Jane E Blackmer, Chenyang Jiang, Steven A Yukl, Eric S Rosenberg, G Yu Xu, Mathias Lichterfeld. Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses. 2022 Cell.185 (2), 266-282. e15
7. Xiaodong Lian, Ce Gao, Xiaoming Sun, Chenyang Jiang, Kevin B Einkauf, Kyra W Seiger, Joshua M Chevalier, Yuko Yuki, Maureen Martin, Rebecca Hoh, Michael J Peluso, Mary Carrington, Ezequiel Ruiz-Mateos, Steven G Deeks, Eric S Rosenberg, Bruce D Walker, Mathias Lichterfeld, Xu G Yu.Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers. 2021,Science translational medicine.13 (624), eabl4097
8. Ellen Shrock, Eric Fujimura, Tomasz Kula, Richard T Timms, I-Hsiu Lee, Yumei Leng, Matthew L Robinson, Brandon M Sie, Mamie Z Li, Yuezhou Chen, Jennifer Logue, Adam Zuiani, Denise McCulloch, Felipe JN Lelis, Stephanie Henson, Daniel R Monaco, Meghan Travers, Shaghayegh Habibi, William A Clarke, Patrizio Caturegli, Oliver Laeyendecker, Alicja Piechocka-Trocha, Jonathan Z Li, Ashok Khatri, Helen Y Chu, MGH COVID-19 Collection & Processing Team 16‡, Xiaoming Sun, Alexandra-Chloé Villani, Kyle Kays, Marcia B Goldberg, Nir Hacohen, Michael R Filbin, Xu G Yu, Bruce D Walker, Duane R Wesemann, H Benjamin Larman, James A Lederer, Stephen J Elledge.Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. 2020 Science 370 (6520), eabd4250
9. Jesse Fajnzylber, James Regan, Kendyll Coxen, Heather Corry, Colline Wong, Alexandra Rosenthal, Daniel Worrall, Francoise Giguel, Alicja Piechocka-Trocha, Caroline Atyeo, Stephanie Fischinger, Andrew Chan, Keith T Flaherty, Kathryn Hall, Michael Dougan, Edward T Ryan, Elizabeth Gillespie, Rida Chishti, Yijia Li, Nikolaus Jilg, Dusan Hanidziar, Rebecca M Baron, Lindsey Baden, Athe M Tsibris, Katrina A Armstrong, Daniel R Kuritzkes, Galit Alter, Bruce D Walker, Xu Yu, Jonathan Z Li.SARS-CoV-2 viral load is associated with increased disease severity and mortality. 2020 Nature communications 11 (1), 1-9
10. Naoki Kaneko, Hsiao-Hsuan Kuo, Julie Boucau, Jocelyn R Farmer, Hugues Allard-Chamard, Vinay S Mahajan, Alicja Piechocka-Trocha, Kristina Lefteri, Matthew Osborn, Julia Bals, Yannic C Bartsch, Nathalie Bonheur, Timothy M Caradonna, Josh Chevalier, Fatema Chowdhury, Thomas J Diefenbach, Kevin Einkauf, Jon Fallon, Jared Feldman, Kelsey K Finn, Pilar Garcia-Broncano, Ciputra Adijaya Hartana, Blake M Hauser, Chenyang Jiang, Paulina Kaplonek, Marshall Karpell, Eric C Koscher, Xiaodong Lian, Hang Liu, Jinqing Liu, Ngoc L Ly, Ashlin R Michell, Yelizaveta Rassadkina, Kyra Seiger, Libera Sessa, Sally Shin, Nishant Singh, Weiwei Sun, Xiaoming Sun, Hannah J Ticheli, Michael T Waring, Alex L Zhu, Galit Alter, Jonathan Z Li, Daniel Lingwood, Aaron G Schmidt, Mathias Lichterfeld, Bruce D Walker, G Yu Xu, Robert F Padera Jr, Shiv Pillai, Massachusetts Consortium on Pathogen Readiness Specimen Working Group.Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19.2020/10/1Cell 183 (1), 143-157. e13
11. Chenyang Jiang, Xiaodong Lian, Ce Gao, Xiaoming Sun, Kevin B Einkauf, Joshua M Chevalier, Samantha MY Chen, Stephane Hua, Ben Rhee, Kaylee Chang, Jane E Blackmer, Matthew Osborn, Michael J Peluso, Rebecca Hoh, Ma Somsouk, Jeffrey Milush, Lynn N Bertagnolli, Sarah E Sweet, Joseph A Varriale, Peter D Burbelo, Tae-Wook Chun, Gregory M Laird, Erik Serrao, Alan N Engelman, Mary Carrington, Robert F Siliciano, Janet M Siliciano, Steven G Deeks, Bruce D Walker, Mathias Lichterfeld, Xu G Yu.Distinct viral reservoirs in individuals with spontaneous control of HIV-1.2020 Nature 585 (7824), 261-267
12. Kevin B Einkauf, Guinevere Q Lee, Ce Gao, Radwa Sharaf, Xiaoming Sun, Stephane Hua, Samantha MY Chen, Chenyang Jiang, Xiaodong Lian, Fatema Z Chowdhury, Eric S Rosenberg, Tae-Wook Chun, Jonathan Z Li, G Yu Xu, Mathias Lichterfeld.Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy.2019 The Journal of clinical investigation 129 (3), 988-998
13. Kuse Nozomi, Sun Xiaoming, Akahoshi Tomohiro, Lissina Anya, Yamamoto Takuya, Appay Victor, Takiguchi Masafumi.Priming of HIV-1-specific CD8+ T cells with strong functional properties from naïve T cells.2019 EBioMedicine 42, 109-119
14. Radwa Sharaf, Guinevere Q Lee, Xiaoming Sun, Behzad Etemad, Layla M Aboukhater, Zixin Hu, Zabrina L Brumme, Evgenia Aga, Ronald J Bosch, Ying Wen, Golnaz Namazi, Ce Gao, Edward P Acosta, Rajesh T Gandhi, Jeffrey M Jacobson, Daniel Skiest, David M Margolis, Ronald Mitsuyasu, Paul Volberding, Elizabeth Connick, Daniel R Kuritzkes, Michael M Lederman, G Yu Xu, Mathias Lichterfeld, Jonathan Z Li.HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers.2018 The Journal of clinical investigation 128 (9), 4074-4085
15. Mohamed Shehata Draz, Manasa Venkataramani, Harini Lakshminarayanan, Ecem Saygili, Maryam Moazeni, Anish Vasan, Yudong Li, Xiaoming Sun, Stephane Hua, G Yu Xu, Hadi Shafiee.Nanoparticle-enhanced electrical detection of Zika virus on paper microchips.2018 Nanoscale10 (25), 11841-11849
16. Xiaoming Sun, Stephane Hua, Hsiao-Rong Chen, Zhengyu Ouyang, Kevin Einkauf, Samantha Tse, Kevin Ard, Andrea Ciaranello, Sigal Yawetz, Paul Sax, Eric S Rosenberg, Mathias Lichterfeld, G Yu Xu.Transcriptional changes during naturally acquired Zika virus infection render dendritic cells highly conducive to viral replication.2017 Cell reports 21 (12), 3471-3482
17. Nina Orlova-Fink, Fatema Z Chowdhury, Xiaoming Sun, Sean Harrington, Eric S Rosenberg, Mathias LICHTERFELD.Preferential susceptibility of Th9 and Th2 CD4 T cells to X4-tropic HIV-1infection.2017AIDS (London, England)31 (16), 2211
18. Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, Masafumi Takiguchi.HIV-1 control by NK cells via reduced interaction between KIR2DL2 and HLA-C∗ 12: 02/C∗ 14: 03.2016 Cell reports 17 (9), 2210-2220
19.Xiaoming Sun, Yi Shi, Tomohiro Akahoshi, Mamoru Fujiwara, Hiroyuki Gatanaga, Christian Schönbach, Nozomi Kuse, Victor Appay, George F Gao, Shinichi Oka, Masafumi Takiguchi.Effects of a single escape mutation on T cell and HIV-1 co-adaptation.2016 Cell reports 15 (10), 2279-2291
20.Behzad Etemad, Xiaoming Sun, Michael M Lederman, RZ Gottlieb, E Aga, R Bosch, JM Jacobson, RT Gandhi, X Yu, JZ Li.Viral and immune characteristics of HIV post-treatment controllers in ACTG studies.2016 Conference on Retroviruses and Opportunistic Infections (CROI) 22-25
21. Xiaoming Sun, Xiaoguang Li.Biography of Professor Chiao-Ju Wu.2015 Journal of Applied Virology 4 (1), 1-3
22. Xiaoming Sun, Mamoru Fujiwara, Yi Shi, Nozomi Kuse, Hiroyuki Gatanaga, Victor Appay, George F Gao, Shinichi Oka, Masafumi Takiguchi.Superimposed epitopes restricted by the same HLA molecule drive distinct HIV-specific CD8+ T cell repertoires.2014 The Journal of Immunology 193 (1), 77-84
23. Chihiro Motozono, Nozomi Kuse, Xiaoming Sun, Pierre J Rizkallah, Anna Fuller, Shinichi Oka, David K Cole, Andrew K Sewell, Masafumi Takiguchi.Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B* 51: 01.2014 The Journal of Immunology 192 (7), 3428-3434
24. Xiaoming Sun, Masumichi Saito, Yoshinori Sato, Takayuki Chikata, Takuya Naruto, Tatsuhiko Ozawa, Eiji Kobayashi, Hiroyuki Kishi, Atsushi Muraguchi, Masafumi Takiguchi.Unbiased analysis of TCRα/β chains at the single-cell level in human CD8+ T-cell subsets.2012 PloS one 7 (7), e40386
25.GQ Lee, N Orlova-Fink, K Einkauf, FZ Chowdhury, Xiaoming Sun, S Harrington, HH Kuo, S Hua.Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells.2017 J Clin Invest 127, 2689-2696
